| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Fernando Martinez | UD Almeria | Spain | 64 | |
| 2 | Edgar Badia | Elche CF | Spain | 63 | |
| 3 | Stole Dimitrievski | Rayo Vallecano | North Macedonia | 54 | |
| 4 | Jeremias Ledesma | Cadiz CF | Argentina | 49 | |
| 5 | Giorgi Mamardashvili | Valencia | Georgia | 47 | |
| 6 | David Soria | Getafe | Spain | 45 | |
| 7 | Jordi Masip | Real Valladolid | Spain | 43 | |
| 8 | Yassine Bounou | Sevilla | Morocco | 42 | |
| 9 | Predrag Rajkovic | RCD Mallorca | Serbia | 41 | |
| 10 | Alejandro Remiro | Real Sociedad | Spain | 39 | |
| 11 | Paulo Gazzaniga | Girona FC | Argentina | 39 | |
| 12 | Unai Simon | Athletic Bilbao | Spain | 38 | |
| 13 | Fernando Pacheco | UD Almeria | Spain | 36 | |
| 14 | Rui Silva | Real Betis | Portugal | 34 | |
| 15 | Thibaut Courtois | Real Madrid | Belgium | 31 | |
| 16 | Agustin Marchesin | Celta Vigo | Argentina | 29 | |
| 17 | Pepe Reina | Villarreal | Spain | 28 | |
| 18 | Ivan Villar | Celta Vigo | Spain | 26 | |
| 19 | Sergio Herrera | Osasuna | Spain | 23 | |
| 20 | Sergio Asenjo | Real Valladolid | Spain | 21 |
GC = Goals conceded