| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Clement Diop | Montreal Impact | France | 26 | |
| 2 | Daniel Vega | San Jose Earthquakes | Argentina | 19 | |
| 3 | Marko Maric | Houston Dynamo | Croatia | 16 | |
| 4 | Brad Guzan | Atlanta United | United States | 15 | |
| 5 | Steve Clark | Portland Timbers | United States | 15 | |
| 6 | Luis Robles | Inter Miami CF | United States | 14 | |
| 7 | Andrew Putna | Real Salt Lake | United States | 14 | |
| 8 | Pablo Sisniega | Los Angeles FC | Mexico | 13 | |
| 9 | David Bingham | Los Angeles Galaxy | United States | 13 | |
| 10 | Andre Blake | Philadelphia Union | Jamaica | 12 | |
| 11 | Bill Hamid | DC United | United States | 12 | |
| 12 | Sean Johnson | New York City | United States | 11 | |
| 13 | Matt Turner | New England Revolution | United States | 10 | |
| 14 | Stefan Frei | Seattle Sounders | Switzerland | 10 | |
| 15 | Spencer Richey | Cincinnati | United States | 9 | |
| 16 | Thomas Hasal | Vancouver Whitecaps | Canada | 9 | |
| 17 | Jimmy Maurer | FC Dallas | United States | 8 | |
| 18 | Eloy Room | Columbus Crew | Curacao | 8 | |
| 19 | Joe Willis | Nashville SC | United States | 8 | |
| 20 | Bobby Shuttleworth | Chicago Fire | United States | 8 |
GC = Goals conceded