| A(D) | Clubs | VS | MD | |
|---|---|---|---|---|
| 20(93) | Reading | Swansea City | 10-Aug-2021 | Match Details |
| 22(329) | Brighton & Hove Albion | Cardiff City | 24-Aug-2021 | Match Details |
| 22(8) | AFC Wimbledon | Charlton Athletic | 10-Aug-2021 | Match Details |
| 22(76) | Carlisle United | Sheffield United | 10-Aug-2021 | Match Details |
| 23(213) | Manchester City | Wycombe Wanderers | 21-Sep-2021 | Match Details |
| 23(252) | Nottingham Forest | Bradford City | 11-Aug-2021 | Match Details |
| 23(295) | Peterborough United | Plymouth Argyle | 10-Aug-2021 | Match Details |
| 23(18) | Milton Keynes Dons | AFC Bournemouth | 31-Jul-2021 | Match Details |
| 23(18) | Barnsley | Bolton Wanderers | 10-Aug-2021 | Match Details |
| 23(110) | Doncaster Rovers | Stoke City | 24-Aug-2021 | Match Details |
| 23(113) | Hull City | Wigan Athletic | 10-Aug-2021 | Match Details |
| 23(140) | Accrington Stanley | Oldham Athletic | 24-Aug-2021 | Match Details |
| 23(141) | West Bromwich Albion | Arsenal | 25-Aug-2021 | Match Details |
| 23(170) | Ipswich Town | Newport County | 10-Aug-2021 | Match Details |
| 23(174) | Brentford | Forest Green Rovers | 24-Aug-2021 | Match Details |
| 23(182) | Arsenal | Liverpool | 20-Jan-2022 | Match Details |
| 23(187) | Liverpool | Norwich City | 21-Sep-2021 | Match Details |
| 24(192) | Cambridge United | Millwall | 24-Aug-2021 | Match Details |
| 24(238) | Swansea City | Reading | 10-Aug-2021 | Match Details |
| 24(257) | Sunderland | Blackpool | 24-Aug-2021 | Match Details |
| 24(269) | Blackburn Rovers | Morecambe | 10-Aug-2021 | Match Details |
| 24(282) | Coventry City | Northampton Town | 11-Aug-2021 | Match Details |
| 24(289) | Derby County | Salford City | 10-Aug-2021 | Match Details |
| 24(302) | Crewe Alexandra | Leeds United | 24-Aug-2021 | Match Details |
| 24(304) | Forest Green Rovers | Brentford | 24-Aug-2021 | Match Details |
| 24(325) | Swindon Town | Cambridge United | 10-Aug-2021 | Match Details |
| 24(350) | Norwich City | AFC Bournemouth | 24-Aug-2021 | Match Details |
| 24(5) | AFC Bournemouth | Milton Keynes Dons | 31-Jul-2021 | Match Details |
| 24(23) | Rochdale | Shrewsbury Town | 24-Aug-2021 | Match Details |
| 24(27) | Queens Park Rangers | Oxford United | 24-Aug-2021 | Match Details |
| 24(35) | Lincoln City | Shrewsbury Town | 10-Aug-2021 | Match Details |
| 24(55) | Sheffield United | Derby County | 24-Aug-2021 | Match Details |
| 24(67) | Plymouth Argyle | Swansea City | 24-Aug-2021 | Match Details |
| 24(97) | Stoke City | Brentford | 27-Oct-2021 | Match Details |
| 24(170) | Bristol Rovers | Cheltenham Town | 10-Aug-2021 | Match Details |
| 25(202) | Blackpool | Middlesbrough | 11-Aug-2021 | Match Details |
| 25(238) | Middlesbrough | Blackpool | 11-Aug-2021 | Match Details |
| 25(255) | Tottenham Hotspur | Wolverhampton Wanderers | 22-Sep-2021 | Match Details |
| 25(259) | Birmingham City | Colchester United | 10-Aug-2021 | Match Details |
| 25(273) | Cheltenham Town | Bristol Rovers | 10-Aug-2021 | Match Details |
| 25(283) | Wolverhampton Wanderers | Tottenham Hotspur | 22-Sep-2021 | Match Details |
| 25(296) | Southampton | Sheffield United | 21-Sep-2021 | Match Details |
| 25(300) | Leeds United | Fulham | 21-Sep-2021 | Match Details |
| 25(307) | Aston Villa | Barrow | 24-Aug-2021 | Match Details |
| 25(329) | Chelsea | Brentford | 22-Dec-2021 | Match Details |
| 25(349) | Leicester City | Brighton & Hove Albion | 27-Oct-2021 | Match Details |
| 25(357) | Northampton Town | Coventry City | 11-Aug-2021 | Match Details |
| 25(360) | Oxford United | Queens Park Rangers | 24-Aug-2021 | Match Details |
| 25(0) | Fleetwood Town | Stoke City | 10-Aug-2021 | Match Details |
| 25(14) | Morecambe | Blackburn Rovers | 10-Aug-2021 | Match Details |
| 25(28) | Newport County | Ipswich Town | 10-Aug-2021 | Match Details |
| 25(69) | Oldham Athletic | Accrington Stanley | 24-Aug-2021 | Match Details |
| 25(79) | Charlton Athletic | AFC Wimbledon | 10-Aug-2021 | Match Details |
| 25(90) | Leyton Orient | Queens Park Rangers | 11-Aug-2021 | Match Details |
| 25(104) | Everton | Huddersfield Town | 24-Aug-2021 | Match Details |
| 25(118) | Bristol City | Forest Green Rovers | 10-Aug-2021 | Match Details |
| 25(120) | Walsall | Doncaster Rovers | 10-Aug-2021 | Match Details |
| 25(123) | Mansfield Town | Preston North End | 10-Aug-2021 | Match Details |
| 25(125) | Wigan Athletic | Hull City | 10-Aug-2021 | Match Details |
| 25(147) | Exeter City | Wycombe Wanderers | 10-Aug-2021 | Match Details |
| 26(241) | Colchester United | Birmingham City | 10-Aug-2021 | Match Details |
| 26(268) | Scunthorpe United | Barrow | 10-Aug-2021 | Match Details |
| 26(283) | Stevenage | Wycombe Wanderers | 24-Aug-2021 | Match Details |
| 26(286) | Gillingham | Crawley Town | 10-Aug-2021 | Match Details |
| 26(299) | West Ham United | Tottenham Hotspur | 22-Dec-2021 | Match Details |
| 26(333) | Huddersfield Town | Sheffield Wednesday | 01-Aug-2021 | Match Details |
| 26(335) | Rotherham United | Accrington Stanley | 10-Aug-2021 | Match Details |
| 26(9) | Burton Albion | Oxford United | 11-Aug-2021 | Match Details |
| 26(14) | Crawley Town | Gillingham | 10-Aug-2021 | Match Details |
| 26(39) | Luton Town | Stevenage | 10-Aug-2021 | Match Details |
| 26(69) | Wycombe Wanderers | Stevenage | 24-Aug-2021 | Match Details |
| 26(104) | Fulham | Birmingham City | 24-Aug-2021 | Match Details |
| 26(109) | Hartlepool United | Crewe Alexandra | 10-Aug-2021 | Match Details |
| 26(183) | Bradford City | Nottingham Forest | 11-Aug-2021 | Match Details |
| 27(213) | Portsmouth | Millwall | 10-Aug-2021 | Match Details |
| 27(237) | Barrow | Scunthorpe United | 10-Aug-2021 | Match Details |
| 27(274) | Preston North End | Liverpool | 27-Oct-2021 | Match Details |
| 27(311) | Cardiff City | Sutton United | 10-Aug-2021 | Match Details |
| 27(329) | Watford | Stoke City | 21-Sep-2021 | Match Details |
| 27(22) | Manchester United | West Ham United | 22-Sep-2021 | Match Details |
| 27(33) | Sheffield Wednesday | Huddersfield Town | 01-Aug-2021 | Match Details |
| 27(66) | Shrewsbury Town | Lincoln City | 10-Aug-2021 | Match Details |
| 27(87) | Millwall | Cambridge United | 24-Aug-2021 | Match Details |
| 27(102) | Newcastle United | Burnley | 25-Aug-2021 | Match Details |
| 27(184) | Salford City | Derby County | 10-Aug-2021 | Match Details |
| 28(216) | Crystal Palace | Watford | 24-Aug-2021 | Match Details |
| 28(265) | Port Vale | Sunderland | 10-Aug-2021 | Match Details |
| 28(291) | Bolton Wanderers | Wigan Athletic | 24-Aug-2021 | Match Details |
| 28(56) | Tranmere Rovers | Oldham Athletic | 10-Aug-2021 | Match Details |
| 28(63) | Sutton United | Cardiff City | 10-Aug-2021 | Match Details |
| 29(215) | Burnley | Tottenham Hotspur | 27-Oct-2021 | Match Details |
MD = Match date,
A(D) = Age(Days).