| A(D) | Clubs | VS | MD | |
|---|---|---|---|---|
| 23(235) | Seattle Sounders | Austin FC | 23-Jul-2021 | Match Details |
| 23(268) | New York Red Bulls | Nashville SC | 19-Jun-2021 | Match Details |
| 23(111) | FC Dallas | New York City | 15-Sep-2021 | Match Details |
| 23(129) | Los Angeles FC | Los Angeles Galaxy | 29-Aug-2021 | Match Details |
| 24(294) | Philadelphia Union | New England Revolution | 08-Aug-2021 | Match Details |
| 24(14) | Vancouver Whitecaps | Los Angeles FC | 25-Jul-2021 | Match Details |
| 24(32) | Montreal Impact | DC United | 09-Aug-2021 | Match Details |
| 24(185) | Atlanta United | Cincinnati | 22-Jul-2021 | Match Details |
| 25(246) | Austin FC | Minnesota United | 24-Jun-2021 | Match Details |
| 25(249) | Los Angeles Galaxy | Minnesota United | 14-Aug-2021 | Match Details |
| 25(275) | New York City | Atlanta United | 24-Jun-2021 | Match Details |
| 25(363) | San Jose Earthquakes | Real Salt Lake | 08-May-2021 | Match Details |
| 25(364) | Chicago Fire | Columbus Crew | 20-Jun-2021 | Match Details |
| 25(35) | Portland Timbers | FC Dallas | 02-May-2021 | Match Details |
| 25(38) | Orlando City | Chicago Fire | 08-Jul-2021 | Match Details |
| 26(196) | New England Revolution | Atlanta United | 02-May-2021 | Match Details |
| 26(234) | Toronto FC | Montreal Impact | 17-Apr-2021 | Match Details |
| 26(273) | DC United | Toronto FC | 03-Jul-2021 | Match Details |
| 26(276) | Houston Dynamo | Colorado Rapids | 31-Oct-2021 | Match Details |
| 26(337) | Colorado Rapids | Portland Timbers | 16-Sep-2021 | Match Details |
| 26(0) | Sporting Kansas City | Real Salt Lake | 01-May-2021 | Match Details |
| 26(20) | Real Salt Lake | FC Dallas | 23-May-2021 | Match Details |
| 26(104) | Cincinnati | New York City | 24-Apr-2021 | Match Details |
| 27(200) | Inter Miami CF | Toronto FC | 15-Sep-2021 | Match Details |
| 27(137) | Nashville SC | New England Revolution | 05-Aug-2021 | Match Details |
| 28(197) | Minnesota United | Seattle Sounders | 18-Jul-2021 | Match Details |
| 28(93) | Columbus Crew | Toronto FC | 13-May-2021 | Match Details |
MD = Match date,
A(D) = Age(Days).