| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Jan Oblak | 38 | 38 | - | - | - | - |
Marcos Llorente | 36 | 28 | 8 | 8 | 12 | 6 |
Jorge Koke | 35 | 32 | 3 | 3 | 14 | - |
Axel Witsel | 35 | 30 | 6 | 5 | 3 | 2 |
Rodrigo de Paul | 34 | 25 | 9 | 9 | 19 | 3 |
Samuel Lino | 34 | 25 | 11 | 9 | 19 | 4 |
Rodrigo Riquelme | 34 | 17 | 21 | 17 | 13 | 3 |
Antoine Griezmann | 33 | 31 | 3 | 2 | 11 | 16 |
Saul Niguez | 33 | 14 | 23 | 19 | 9 | 1 |
Alvaro Morata | 32 | 21 | 13 | 11 | 14 | 15 |
Angel Correa | 32 | 14 | 21 | 18 | 10 | 9 |
Mario Hermoso | 31 | 29 | 6 | 2 | 3 | - |
Nahuel Molina | 30 | 19 | 13 | 11 | 11 | 2 |
Pablo Barrios | 24 | 17 | 7 | 7 | 9 | - |
Cesar Azpilicueta | 24 | 14 | 15 | 10 | 8 | - |
Stefan Savic | 23 | 19 | 13 | 4 | 3 | - |
Memphis Depay | 23 | 9 | 17 | 14 | 9 | 5 |
Jose Maria Gimenez | 22 | 14 | 10 | 8 | 4 | - |
Reinildo Mandava | 16 | 7 | 17 | 9 | 1 | 2 |
Caglar Soyuncu | 6 | 1 | 13 | 5 | 1 | - |
Gabriel Paulista | 5 | 5 | 9 | - | 1 | - |
Arthur Vermeeren | 5 | 2 | 16 | 3 | 2 | - |
Javi Galan | 5 | - | 20 | 5 | - | - |
Thomas Lemar | 3 | 3 | 2 | - | 3 | - |
Yannick Carrasco | 3 | 3 | - | - | 2 | - |
Marco Moreno | 1 | 1 | 6 | - | - | - |
Salim El Jebari | 1 | - | 8 | 1 | - | - |
Abdellah Raihani | 1 | - | 1 | 1 | - | - |
Adrian Nino | - | - | 2 | - | - | - |
Sergio Mestre | - | - | 1 | - | - | - |
Ilias Kostis | - | - | 8 | - | - | - |
Aitor Gismera | - | - | 3 | - | - | - |
Rayane Belaid | - | - | 1 | - | - | - |
Ivo Grbic | - | - | 18 | - | - | - |
Antonio Gomis | - | - | 38 | - | - | - |
Horatiu Moldovan | - | - | 18 | - | - | - |
Joao Felix | - | - | 2 | - | - | - | 599 | 418 | 382 | 181 | 181 | 68 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .